HPDB: Human Pigmentation Database
FAQs


Sl no Reference Journal Publication year Allele Population Sub populations Gene SNP Amino acid change Trait Discovery OR (95% CI) Replication 1 OR (95% CI) Replication 2 OR (95% CI) p value Chromosome Functional Consequence
81 Pavan et al. Annual Review of Genomics and Human Genetics 2019 C > A Others African, Latin Americans, Europeans TYR rs1042602 NA Skin, hair, eye color NA NA NA NA 11 Intragenic
G > A Others African, Latin Americans, Europeans TYR rs1126809 R402Q Skin, hair, eye color NA NA NA NA 11 Intragenic
G>A Others African, Latin Americans, Europeans OCA2 rs12913832 NA Skin, hair, eye color NA NA NA NA 15 Intragenic
A>G,T Others African, Latin Americans, Europeans OCA2 rs7495174 NA Skin, hair, eye color NA NA NA NA 15 Intragenic
A>C Others African, Latin Americans, Europeans OCA2 rs4778241 NA Skin, hair, eye color NA NA NA NA 15 Intragenic
A>C,G,T Others African, Latin Americans, Europeans OCA2 rs4778138 NA Skin, hair, eye color NA NA NA NA 15 Intragenic
A>G Others African, Latin Americans, Europeans OCA2 rs1448484 NA NA NA NA NA NA 15 Intragenic
G>A Others African, Latin Americans, Europeans OCA2 rs1800401 R305W Eye, skin color NA NA NA NA 15 Intragenic
C>T Others African, Latin Americans, Europeans OCA2 rs1800407 R419Q Eye, skin color NA NA NA NA 15 Intragenic
C>T Others African, Latin Americans, Europeans OCA2 rs121918166 V419I Eye, skin color NA NA NA NA 15 Intragenic
G>A Others African, Latin Americans, Europeans OCA2 rs74653330 NA Skin color NA NA NA NA 15 Intragenic
T>A,C Others African, Latin Americans, Europeans OCA2 rs1800414 H591R Skin color NA NA NA NA 15 Intragenic
C > T Others African, Latin Americans, Europeans TYRP1 rs1408799 NA Skin, hair, eye color NA NA NA NA 9 NA
C>T Others African, Latin Americans, Europeans TYRP1 rs387907171 NA Hair color NA NA NA NA 9 Intragenic
G>A,T Others African, Latin Americans, Europeans TYRP1 rs61752937 NA NA NA NA NA NA 9 Intragenic
G>A Others African, Latin Americans, Europeans SLC45A2 rs26722 NA Skin color NA NA NA NA 5 Intragenic
C>G Others African, Latin Americans, Europeans SLC45A2 rs16891982 NA Skin, hair, eye color NA NA NA NA 5 Intragenic
A>G,T Others African, Latin Americans, Europeans SLC24A5 rs1426654 NA Skin, hair, eye color NA NA NA NA 15 Intragenic
A>G Others African, Latin Americans, Europeans LRMDA rs11001536 NA Skin color NA NA NA NA 10 Intragenic
C>A,T Others African, Latin Americans, Europeans LRMDA rs35349706 NA NA NA NA NA NA 10 Intragenic
G>A,T Others African, Latin Americans, Europeans LRMDA rs75852090 NA NA NA NA NA NA 10 Intragenic
A>C,G,T Others African, Latin Americans, Europeans LRMDA rs7923619 NA NA NA NA NA NA 10 Intragenic
A > G Others African, Latin Americans, Europeans ASIP rs4911442 NA Skin, hair, eye color NA NA NA NA 20 Intragenic
A>G Others African, Latin Americans, Europeans ASIP rs6059655 NA NA NA NA NA NA 20 Intragenic
C>G,T Others African, Latin Americans, Europeans BNC2 rs2153271 NA Skin color NA NA NA NA 9 Intragenic
NA Others African, Latin Americans, Europeans BNC2 rs10765819 NA NA NA NA NA NA 9 Intragenic
G>A,C,T Others African, Latin Americans, Europeans BNC2 rs12350739 NA NA NA NA NA NA 9 NA
C>A,G Others African, Latin Americans, Europeans BNC2 rs62543565 NA NA NA NA NA NA 9 NA
T>A,C,G Others African, Latin Americans, Europeans DUT rs1407995 NA Hair color NA NA NA NA 15 Intragenic
A>G Others African, Latin Americans, Europeans DUT rs2031526 NA Hair color NA NA NA NA 15 Intragenic
C > T Others African, Latin Americans, Europeans IRF4 rs12203592 NA Skin, hair, eye color NA NA NA NA 6 Intragenic
G>A,C,T Others African, Latin Americans, Europeans KIT rs115585711 NA Hair, skin color NA NA NA NA 4 Intragenic
A>C,G,T Others African, Latin Americans, Europeans KIT rs3822214 NA Hair, skin color NA NA NA NA 4 Intragenic
T>A,C,G Others African, Latin Americans, Europeans KITLG rs12821256 NA Hair, skin color NA NA NA NA 12 NA
C>T Others African, Latin Americans, Europeans MC1R rs3212379 NA Hair, skin color NA NA NA NA 16 Intragenic
G>T Others African, Latin Americans, Europeans MC1R rs1805005 NA Hair, skin color NA NA NA NA 16 Intragenic
C>A Others African, Latin Americans, Europeans MC1R rs1805006 NA Hair, skin color NA NA NA NA 16 Intragenic
G>A Others African, Latin Americans, Europeans MC1R rs2228479 NA Hair, skin color NA NA NA NA 16 Intragenic
C>T Others African, Latin Americans, Europeans MC1R rs34158934 NA Hair, skin color NA NA NA NA 16 Intragenic
G>A Others African, Latin Americans, Europeans MC1R rs11547464 NA Hair, skin color NA NA NA NA 16 Intragenic
C>T Others African, Latin Americans, Europeans MC1R rs1805007 NA Hair, skin color NA NA NA NA 16 Intragenic
C>A Others African, Latin Americans, Europeans MC1R rs201326893 NA Hair, skin color NA NA NA NA 16 Intragenic
T>C Others African, Latin Americans, Europeans MC1R rs1110400 NA Hair, skin color NA NA NA NA 16 Intragenic
C>T Others African, Latin Americans, Europeans MC1R rs1805008 NA Hair, skin color NA NA NA NA 16 Intragenic
G>A Others African, Latin Americans, Europeans MC1R rs885479 NA Hair, skin color NA NA NA NA 16 Intragenic
->c Others African, Latin Americans, Europeans MC1R rs555179612 NA Hair, skin color NA NA NA NA 16 Intragenic
C>G,T Others African, Latin Americans, Europeans MC1R rs200000734 NA Hair, skin color NA NA NA NA 16 Intragenic
G>A,C Others African, Latin Americans, Europeans MC1R rs1805009 NA Hair, skin color NA NA NA NA 16 Intragenic
G>A Others African, Latin Americans, Europeans MC1R rs368507952 NA Hair, skin color NA NA NA NA 16 Intragenic
G>A,T Others African, Latin Americans, Europeans MC1R rs149617956 NA Skin, hair, eye color NA NA NA NA 16 Intragenic
T>C Others African, Latin Americans, Europeans MC1R rs9823839 NA Hair color NA NA NA NA 16 Intragenic
NA Others African, Latin Americans, Europeans POMC rs7664S364 NA Hair color NA NA NA NA 2 NA
G > T Others African, Latin Americans, Europeans SLC24A4 rs12896399 NA Eye color NA NA NA NA 14 Intragenic
A>G,T Others African, Latin Americans, Europeans SLC24A4 rs8014907 NA Eye color NA NA NA NA 14 Intragenic
C>T Others African, Latin Americans, Europeans TPCN2 rs72930659 NA Hair color NA NA NA NA 11 NA
G>A Others African, Latin Americans, Europeans TPCN2 rs72928978 NA Hair color NA NA NA NA 11 Intragenic
A>C,G Others African, Latin Americans, Europeans TPCN2 rs3750965 NA Hair color NA NA NA NA 11 Intragenic
A>T Others African, Latin Americans, Europeans TPCN2 rs35264875 NA Hair color NA NA NA NA 11 Intragenic
G>A Others African, Latin Americans, Europeans TPCN2 rs3829241 NA Skin color NA NA NA NA 11 Intragenic
G>A Others African, Latin Americans, Europeans TPCN2 rs4930263 NA Skin color NA NA NA NA 11 Intragenic
C>T Others African, Latin Americans, Europeans TPCN2 rs2376558 NA Hair, skin color NA NA NA NA 11 Intragenic
G>T Others African, Latin Americans, Europeans TPCN2 rs10896418 NA Hair color NA NA NA NA 11 3 prime UTR
G>C Others African, Latin Americans, Europeans SLC45A1 rs80293268 NA Hair color NA NA NA NA 1 Intragenic
T>C Others African, Latin Americans, Europeans DSTYK rs2369633 NA Hair color NA NA NA NA 1 Upstream
G>C Others African, Latin Americans, Europeans FOSL2 rs71443018 NA Hair color NA NA NA NA 2 Intragenic
C>T Others African, Latin Americans, Europeans LHX2 rs58979150 NA Hair color NA NA NA NA 9 Intergenic
C>A,T Others African, Latin Americans, Europeans BCAS1 rs7313291 NA Hair color NA NA NA NA NA Intragenic
G>A Others African, Latin Americans, Europeans FGF5 rs7681907 NA Hair color NA NA NA NA 4 Intragenic
NA Others African, Latin Americans, Europeans SOX5 rs997729 NA Hair color NA NA NA NA 12 NA
A>C,G,T Others African, Latin Americans, Europeans TSPAN10 rs6420484 NA Hair color NA NA NA NA NA Intragenic
T >C Others African, Latin Americans, Europeans PA2G4P4 rs9818780 NA Tanning NA NA NA NA 3 Intragenic
G>C Others African, Latin Americans, Europeans PPARGC1B rs25146 NA Tanning NA NA NA NA NA Intragenic
G>A Others African, Latin Americans, Europeans AHRIAGR3 rs17132860 NA Tanning NA NA NA NA NA NA
C>T Others African, Latin Americans, Europeans TRPSI rs2737212 NA Tanning NA NA NA NA NA Intragenic
C>T Others African, Latin Americans, Europeans EMX2 rs35563099 NA Tanning NA NA NA NA 10 Intergenic
C>T Others African, Latin Americans, Europeans EMX2 rs11198112 NA Tanning NA NA NA NA 10 NA
C>T Others African, Latin Americans, Europeans ATPIIA rs1046793 NA Tanning NA NA NA NA NA Intragenic
A>G Others African, Latin Americans, Europeans KIAA0930 rs1703668 NA Tanning NA NA NA NA 22 NA
C>T Others African, Latin Americans, Europeans BNC2 rs10810650 NA Tanning NA NA NA NA 9 NA
G>T Others African, Latin Americans, Europeans MFSD12 rs5620314 NA Skin color NA NA NA NA 19 NA
G>A Others African, Latin Americans, Europeans MFSD12 rs6510760 NA Skin color NA NA NA NA 19 Intragenic
T>C Others African, Latin Americans, Europeans MFSD12 rs112 332856 NA Skin color NA NA NA NA 19 NA
A>G Others African, Latin Americans, Europeans MFSD12 rs77733715 NA Tanning NA NA NA NA 19 Downstream
T>A Others African, Latin Americans, Europeans DDB1 rs7948523 NA Skin color NA NA NA NA 11 Intragenic
G>A Others African, Latin Americans, Europeans DDB1 rs872257 NA Skin color NA NA NA NA 11 Intragenic
C>T Others African, Latin Americans, Europeans SNX13 rs2110015 NA Skin color NA NA NA NA 7 NA
82 Durazo et al. BMC Genetics 2019 A>T Admixed Cape Verde, Puerto Rico, San Francisco, African-American GRM5, TYR rs10160510 NA Skin color NA NA NA NA 11 Intragenic
C>T Admixed Cape Verde, Puerto Rico, San Francisco, African-American GABRG3, OCA2 rs3098576 NA Skin color NA NA NA NA 15 NA
A>G Admixed Cape Verde, Puerto Rico, San Francisco, African-American OCA2 rs1448484 NA Skin color NA NA NA NA 15 Intragenic
C>G Admixed Cape Verde, Puerto Rico, San Francisco, African-American HERC2 rs1667392 NA Skin color NA NA NA NA 15 Intragenic
A>G Admixed Cape Verde, Puerto Rico, San Francisco, African-American APBA2 rs36194177 NA Skin color NA NA NA NA 15 NA
A>G Admixed Cape Verde, Puerto Rico, San Francisco, African-American FAM189A1 rs2636060 NA Skin color NA NA NA NA 15 Intragenic
A>G Admixed Cape Verde, Puerto Rico, San Francisco, African-American MFSD12 rs10416746 NA Skin color NA NA NA NA 19 NA
G>C,T Admixed Cape Verde, Puerto Rico, San Francisco, African-American SLC45A2 rs35397 NA Skin color NA NA NA NA 5 Intragenic
C>A,G Admixed Cape Verde, Puerto Rico, San Francisco, African-American SLC45A2 rs16891982 NA Skin color NA NA NA NA 5 Intragenic
A>C,G Admixed Cape Verde, Puerto Rico, San Francisco, African-American SLC45A2 rs35407 NA Skin color NA NA NA NA 5 Intragenic
A>T Admixed Cape Verde, Puerto Rico, San Francisco, African-American TYR rs10160510 NA Skin color NA NA NA NA 11 Intragenic
C>A Admixed Cape Verde, Puerto Rico, San Francisco, African-American TYR rs10437581 NA Skin color NA NA NA NA 11 Intragenic
A>C Admixed Cape Verde, Puerto Rico, San Francisco, African-American TYR rs1042602 NA Skin color NA NA NA NA 11 Intragenic
A>G Admixed Cape Verde, Puerto Rico, San Francisco, African-American TYR rs12801588 NA Skin color NA NA NA NA 11 Intragenic
G>A,C Admixed Cape Verde, Puerto Rico, San Francisco, African-American TYR rs28437494 NA Skin color NA NA NA NA 11 NA
G>C,T Admixed Cape Verde, Puerto Rico, San Francisco, African-American TYR rs4121729 NA Skin color NA NA NA NA 11 NA
T>C Admixed Cape Verde, Puerto Rico, San Francisco, African-American TYR rs7925346 NA Skin color NA NA NA NA 11 NA
C>T Admixed Cape Verde, Puerto Rico, San Francisco, African-American OCA2 rs3098576 NA Skin color NA NA NA NA 15 NA
A>G Admixed Cape Verde, Puerto Rico, San Francisco, African-American OCA2 rs1448484 NA Skin color NA NA NA NA 15 Intragenic
G>A Admixed Cape Verde, Puerto Rico, San Francisco, African-American OCA2 rs12913832 NA Skin color NA NA NA NA 15 Intragenic
C>G Admixed Cape Verde, Puerto Rico, San Francisco, African-American OCA2 rs1667392 NA Skin color NA NA NA NA 15 Intragenic
G>A,T Admixed Cape Verde, Puerto Rico, San Francisco, African-American OCA2 rs36194177 NA Skin color NA NA NA NA 15 NA
A>G Admixed Cape Verde, Puerto Rico, San Francisco, African-American OCA2 rs2636060 NA Skin color NA NA NA NA 15 Intragenic
G>A Admixed Cape Verde, Puerto Rico, San Francisco, African-American OCA2 rs12913832 NA Skin color NA NA NA NA 15 Intragenic
C>T Admixed Cape Verde, Puerto Rico, San Francisco, African-American OCA2 rs1129038 NA Skin color NA NA NA NA 15 3 prime UTR
A>G,T Admixed Cape Verde, Puerto Rico, San Francisco, African-American SLC24A5 rs1426654 NA Skin color NA NA NA NA 15 Intragenic
A>C,G Admixed Cape Verde, Puerto Rico, San Francisco, African-American SLC24A5 rs2470102 NA Skin color NA NA NA NA 15 Intragenic
A>G Admixed Cape Verde, Puerto Rico, San Francisco, African-American MFSD12 rs10416746 NA Skin color NA NA NA NA 19 NA
T>C Admixed Cape Verde, Puerto Rico, San Francisco, African-American MFSD12 rs112332856 NA Skin color NA NA NA NA 19 NA
T>A,C,G Admixed Cape Verde, Puerto Rico, San Francisco, African-American MFSD12 rs80204200 NA Skin color NA NA NA NA 19 Intragenic
A>G Admixed Cape Verde, Puerto Rico, San Francisco, African-American MFSD12 rs7256261 NA Skin color NA NA NA NA 19 Intragenic
G>A,C Admixed Cape Verde, Puerto Rico, San Francisco, African-American MFSD12 rs6510760 NA Skin color NA NA NA NA 19 Intragenic
C>G,T Admixed Cape Verde, Puerto Rico, San Francisco, African-American MFSD12 rs10424065 NA Skin color NA NA NA NA 19 Intragenic
C>A,G,T Admixed Cape Verde, Puerto Rico, San Francisco, African-American MFSD12 rs56203814 NA Skin color NA NA NA NA 19 Intragenic
A>G Admixed Cape Verde, Puerto Rico, San Francisco, African-American BEND7, PRPF18 rs6602666 NA Skin color NA NA NA NA 10 NA
T>C Admixed Cape Verde, Puerto Rico, San Francisco, African-American DDB1 rs11230664 NA Skin color NA NA NA NA 11 Intragenic
C>T Admixed Cape Verde, Puerto Rico, San Francisco, African-American DDB1 rs7120594 NA Skin color NA NA NA NA 11 Intragenic
T>A,C,G Admixed Cape Verde, Puerto Rico, San Francisco, African-American DDB1 rs7948623 NA Skin color NA NA NA NA 11 Intragenic
G>A,C,T Admixed Cape Verde, Puerto Rico, San Francisco, African-American DDB1 rs2513329 NA Skin color NA NA NA NA 11 Intragenic
A>C,G,T Admixed Cape Verde, Puerto Rico, San Francisco, African-American GRM5, TYR rs10831496 NA Skin color NA NA NA NA 11 Intragenic
C>A,T Admixed Cape Verde, Puerto Rico, San Francisco, African-American OCA2 rs1800404 NA Skin color NA NA NA NA 15 Intragenic
T>A,C,G Admixed Cape Verde, Puerto Rico, San Francisco, African-American HERC2 rs4932620 NA Skin color NA NA NA NA 15 Intragenic
C>A,G,T Admixed Cape Verde, Puerto Rico, San Francisco, African-American APBA2 rs4424881 NA Skin color NA NA NA NA 15 Intragenic
G>A Admixed Cape Verde, Puerto Rico, San Francisco, African-American LOC102724084 rs139343937 NA Skin color NA NA NA NA 16 Intragenic
83 Zaorska et al. Human Genetics 2019 A>C European Polish OCA2 rs4778241 NA Skin color NA NA NA 0.0498 15 Intragenic
A>C,G,T European Polish OCA2 rs4778138 NA Skin color NA NA NA 0.0337 15 Intragenic
C>T European Polish OCA2 rs1800407 R419Q Skin color NA NA NA NA 15 Intragenic
A>G,T European Polish VDR rs731236 NA Skin color NA NA NA 0.0097 12 Intragenic
A>G European Polish VDR rs731236 NA Skin color NA NA NA NA 12 Intragenic
A>G European Polish ASIP rs6058017 NA Skin color NA NA NA NA 20 Intragenic
A>G European Polish ASIP rs6058017 NA Skin color NA NA NA NA 20 Intragenic
A>G European Polish ASIP rs1015362 NA Skin color NA NA NA NA 20 NA
T>A,G European Polish ASIP rs1015362 NA Skin color NA NA NA NA 20 NA
T>A,G European Polish ASIP rs4911414 NA Skin color NA NA NA NA 20 NA
C>G,T European Polish ASIP rs4911414 NA Skin color NA NA NA NA 20 NA
C>G,T European Polish IRF4 rs12203592 NA Skin color NA NA NA NA 6 Intragenic
G>A European Polish IRF4 rs12203592 NA Skin color NA NA NA 0.0056 6 Intragenic
G>A European Polish HERC2 rs12913832 NA Skin color NA NA NA NA 15 Intragenic
G>A European Polish HERC2 rs12913832 NA Skin color NA NA NA NA 15 Intragenic
G>A,T European Polish TYR rs1393350 NA Skin color NA NA NA NA 11 Intragenic
G>A,T European Polish SLC24A4 rs12896399 NA Skin color NA NA NA 0.001 14 Intragenic
C>A,G,T European Polish MC1R rs1805007 NA Skin color NA NA NA 0.0018 16 Intragenic
C>A,G European Polish SLC45A2 rs16891982 NA Skin color NA NA NA NA 5 Intragenic
84 Ganguly et al. Archives of Dermatological Research 2019 A>T NA NA CEP152 rs7182710 NA Skin color NA NA NA NA 15 Upstream
G>C NA NA CEP152 rs784416 NA Skin color NA NA NA NA 15 NA
A>G,T NA NA CEP152 rs7176696 NA Skin color NA NA NA NA 15 Intragenic
C>G NA NA ATP8B4 rs937171 NA Skin color NA NA NA NA 15 Intragenic
T>C,G NA NA TYRP1 rs2762462 NA Skin color NA NA NA NA 9 Downstream
C>G,T NA NA MFSD12 rs10424065 NA Skin color NA NA NA NA 19 Intragenic
C>T NA NA MFSD12 rs142317543 NA Skin color NA NA NA NA 19 Intragenic
A>G NA NA MC1R rs3212369 NA Skin color NA NA NA NA 16 3 prime UTR
G>A NA NA MC1R rs3212368 NA Skin color NA NA NA NA 16 3 prime UTR
85 Ju et al. PNAS 2020 C>A,G Others West Eurasian SLC45A2 rs16891982 NA Skin color NA NA NA NA 5 Intragenic
A>G Others West Eurasian TYR rs1126809 R402Q Skin color NA NA NA NA 11 Intragenic
G>A Others West Eurasian HERC2 rs12913832 NA Skin color NA NA NA NA 15 Intragenic
T>G Others West Eurasian HERC2 rs1635168 NA Skin color NA NA NA NA 15 Intragenic
A>G Others West Eurasian GRM5, TYR rs7109255 NA Skin color NA NA NA NA 11 Intragenic
C>T Others West Eurasian EDEM2 rs6120849 NA Skin color NA NA NA NA 20 Intragenic
A>G Others West Eurasian RALGPS1 rs7870409 NA Skin color NA NA NA NA 9 Intragenic
A>C,G,T Others West Eurasian OCA2 rs4778123 NA Skin color NA NA NA NA 15 Intragenic
C>G,T Others West Eurasian BNC2 rs2153271 NA Skin color NA NA NA NA 9 Intragenic
G>A Others West Eurasian CTSC, GRM5 rs3758833 NA Skin color NA NA NA NA 11 Intragenic

Ideated by Genophen Lab,   BHU    &   Bioclues